Uppsala Kidney Oxygen Meeting 2017

Homepage: http://www.mcb.uu.se/kidney2017

SCIENTIFIC DESCRIPTION
Recent advances have solidified deranged renal oxygen homeostasis, i.e.
intrarenal tissue hypoxia, as a key event for both the onset and the
progression of chronic kidney disease (Mimura and Nangaku 2010). In 1998,
Fine and colleagues proposed that reduced renal blood flow in the peritubular
capillaries results in decreased kidney tissue oxygenation which, when
reaching a threshold, promotes tubulointerstitial fibrosis via several
different parallel pathways ultimately leading to chronic kidney
disease (Fine, Orphanides et al. 1998). This theory has gained
increasing support over the last recent years. Specifically,
experimental data have highlighted renal hypoxia as a crucial factor
for kidney disease in diabetes (Rosenberger, Khamaisi et al. 2008),
hypertension (Welch, Baumgartl et al. 2001), polycystic kidney disease
(Bernhardt, Wiesener et al. 2007) and chronic glomerulonephritis
(Inoue, Kozawa et al. 2011). Furthermore, otherwise healthy humans
exposed to reduced kidney tissue oxygenation, due to living at high
altitude, have 1.8-fold increased risk of non-diabetes related
end-stage renal disease (Hochman, Watt et al. 2007). It has also been
reported that renal hypoxia may be an independent mechanism for the
onset of kidney disease (Friederich-Persson, Thorn et al. 2013) and
renal hypoxia is present in patients with diabetes (Inoue, Kozawa et
al. 2011).

The conference will cover the scientific basis of the effects of
hypoxia for cell signaling, mitochondrial and cellular function and
its role in the development of both acute kidney injury and chronic
kidney disease.
We will also thoroughly discuss currently available and novel techniques to
study kidney oxygenation in animal models and patients.

SIGNIFICANCE
It is critical that scientist in the field of kidney oxygen metabolism
can interact to discuss recent findings and form a broad
multidisciplinary group to facilitate collaborations and advance the
current understanding. The creation of a focused group of
world-leading scientists in the rapidly emerging area of the role of
renal hypoxia in kidney disease will certainly be beneficial in order
to allow for exchange of new ideas, identification of possible
collaborations and future research directions.

PARTICIPANTS
We expect approximately 60 attendees with approximately 25% of
participants from Sweden. Invited speakers are especially encourage to bring
graduate students, postdoctoral fellows and junior colleagues that
will benefit from interaction with prominent scientists in the field.
All abstracts will be presented as poster or oral presentations given enough
scientific high and conformation to the scientific theme of the conference.

INTERNATIONAL INVITED SPEAKERS
Ass. Prof. Reiko Inagi, Graduate School of Medicine and Faculty of Medicine,
University of Tokyo, Japan.

Prof. Masaomi Nangaku, Division of Nephrology and Endocrinology, University
of Tokyo School of Medicine, Japan.

Ass. Prof. Prabhleen Singh, University of California, San Diego, USA.

Prof. William Welch, Division of Nephrology and Hypertension, Georgetown
University, USA.

Prof. Susan Francis, School of Physics & Astronomy, University of Nottingham,
United Kingdom.

Prof. Roger Evans, Department of Physiology, Monash University, Australia.

Prof. Jennifer Pollock, Nutrition Obesity Research Center, University of
Alabama at Birmingham, USA.

Dr. Anita T Layton, Biomedical Engineering, Duke University, USA.

Prof. Phillip Darwin Bell, University of Alabama at Birmingham, USA.

Prof. Samuel Heyman, Department of Medicine, Hebrew University of
Jerusalem, Israel.

Prof. Sven-Erik Ricksten, Department of Anesthesiology and Intensive Care,
Gothenburg University, Sweden.

Prof. Volker Haase, Department of Medicine Biochemistry and Biophysics,
Karolinska Institutet, Sweden.

Ass. Prof. Sergiu-Bogdan Catrina, Department of Molecular Medicine and
Surgery, Karolinska Institutet, Sweden.

Dr. Malou Friederich-Persson, Department of Medical Cell Biology, Uppsala
University, Sweden.

Ebba Sivertsson, Department of Medical Cell Biology, Uppsala University,
Sweden.

PROGRAM
August 17-20th 2017
The preliminary program of sessions:
Techniques to measure kidney oxygen homeostasis. Hypoxia inducible factors
and kidney oxygen homeostasis in health and disease. ER-stress and renal
stress responses in the regulation of kidney oxygen homeostasis.
Mitochondrial function and regulation of kidney oxygen homeostasis. The role
of kidney oxygen homeostasis in acute kidney injury. The role of kidney
oxygen homeostasis in chronic kidney disease

“Poster teasers”
In each session, 2-3 abstracts will be selected to be oral
presentations. In the
session called “poster teasers”, poster presenters will get one power point
slide and one minute to present a short teaser and inspire attendees to come
and discuss science at their posters. Each day includes ample time for poster
viewing and poster awards and oral presentations are awarded on a peer-
review basis.

DISSEMINATION ACTIVITIES
All invited speakers and presenters of abstracts will have to opportunity to
submit manuscripts for publication in Acta Physiologica (impact 4.867).
Furthermore, all accepted abstracts will be presented as a joint
volume and distributed to the attendees.

REGISTRATION
For registration please contact: Malou Friederich-Persson at
malou.friederich@mcb.uu.se regarding how to register and for submitting
abstracts.